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Proc. Natl. Acad. Sci. USA 1978, 75, 2636-2640. L. Annu. Rep. Med. Chem. 1978, 13, 227-238. J. L i f e Sciences 1982, 31, 189-199. E. ; Walter de Gruyter: Berlin, 1983, pp. 19-30. T. Amer. , Suppl. 1 1975, 15, 81-96. ; CIBA FOUNDATION SYMPOSIUM 81, Pitman Medical: London, 1981. M. Peptides 1982, 3, 353-395. Medzihradszky, K. ; Publ. House Hung. Acad. S c i . : Budapest, 1976, pp. 119-250. E. Peptide Protein Rev. 1983, i n press. B. Anat. Rec. 1924, 27, 187. S. J . Endocrinol. 1981, 88, 57-65. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1984.
9, 10, and 11. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1984. 44 CONFORMATIONALLY DIRECTED DRUG DESIGN Comments on attempts to predict location of protein antigenic sites. Recenty, based on the foregoing qualitative observations (1,4,35), an empirical approach was suggested (36) which, by linear analysis of the protein sequence i n relation to a hydrophilicity index using the Chou and Fasman (37) method, attempted to correlate antigenic sites with hydropTiTllcity maxima.
3 6 2 nm. The p r e c i s e b o u n d a r y , c o n f o r m a t i o n a l , and d i r e c t i o n a l d e f i n i t i o n s o f t h e s i t e s are d e s c r i b e d i n the t e x t . The t h r e e s i t e s account q u a n t i t a t i v e l y f o r t h e e n t i r e (96 t o 100$) a n t i g e n i c r e a c t i v i t y o f lysozyme. Reproduced w i t h p e r m i s s i o n from R e f . 75. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1984. CONFORMATIONALLY DIRECTED DRUG DESIGN Figure 4.
An Annual publication of satisfactory methods for the preparation of organic chemicals by Organic Syntheses